The mirror acts as a bandpass filter for both the wavelength and the angle, which isolates the desired scattering pattern from nonsample scattering or incoherent emission. Howellsb adepartment of physics and astronomy, arizona state university, tempe, az 852871505, usa blawrence berkeley laboratory, berkeley, ca 94720, usa received 3 september 2003. Femtosecond diffractive imaging with a softxray free. For the successful implementation of extreme ultraviolet euv lithography in the upcoming technol. New xray imaging techniques that come under the general term coherent xray diffractive imaging will impose significant demands on the detector. New coherent diffractive imaging techniques, such fresnel coherent diffractive imaging fcdi, allows quantitative phase information with exceptional dose efficiency, high contrast, and nanoscale. With ability to provide a high resolution image in nanometre scale without the need of the optical lens, cdi has found a vast potential in many disciplines since this method overcomes the manufacturing limit of the xray optics. The short wavelength and element specific interaction of xrays with matter may be exploited to characterise. The epie has been compared to the parallel projection method and to the original pie method using simulated diffraction patterns. Esrf lecture series on coherent xrays and their applications, lecture 7, malcolm howells sayre 1952 fundamentals of sampling the wave amplitude and wave intensity gerchberg and saxton 1972 first phaseretrieval algorithm successful on test data sayre 1980 idea to do crystallography with nonperiodic objects i. A powerful coherent diffractive xray imaging technique could enable next generation synchrotrons and freeelectron lasers to study much larger samples than previously thought possible. Pattern generation system npgs software and patterns. We demonstrate use of a complex constraint based on the interaction of xrays with matter for reconstructing images from coherent xray diffraction.
The workshop will be focused on recent advances and future prospects in imaging technologies and their applications. In cdi, a highly coherent beam of xrays, electrons or other wavelike particle or photon is incident on an object the beam scattered by the object produces a. Dramatic advances in coherent diffractive imaging cdi using light in the extreme. Coherent diffractive imaging cdi has been widely applied in the physical and biological. Fast xray detectors generate vast amounts of data such as the cxi detector at lcls, capable of recording 40tb a day. Keyhole coherent diffractive imaging article pdf available in nature physics 45. Dichroic coherent diffractive imaging article pdf available in proceedings of the national academy of sciences 10833. Fresnel coherent diffractive imaging from periodic samples. John maio ucla, thomas earnest lbnl, david shapiro bnl, enju lima. Coherent diffractive imaging cdi for biological applications at nslsii.
Citeseerx letters keyhole coherent diffractive imaging. Generalized tabletop euv coherent diffractive imaging in a transmission geometry nist. An improved ptychographical phase retrieval algorithm for. Effectively, the objective lens in a typical microscope is replaced with software to convert from the reciprocal space diffraction pattern into a real. Euv microscopy with a tabletop high harmonic generation. The in situ physicochemical analysis of nanostructured functional materials is crucial for advances in their design and production. Digital comprehensive summaries of uppsala dissertations from the faculty of science and technology 1451. Coherence measurements and coherent diffractive imaging at flash i. Researchers rapidly finding new applications for coherent. Xray coherent diffractive imaging cdi is currently under intensive development for a wide range of applications in the materials 1,2,3 and biological sciences 4,5, due in part to its ability to provide spatial resolution beyond the limits imposed by imageforming optics 6. Coherent diffractive imaging cdi has been widely developed to study nanostructures, such as nanocrystals and biological samples. Coherent diffractive imaging is unique as the only route for achieving high spatial resolution in the extreme ultraviolet and xray regions, limited only by the wavelength of. Conventional experiments using cdi assume a perfectly coherent beam and utilize plane wave illumination of the sample. Here we report the first experimental demonstration of this principle using the flash soft xray freeelectron laser.
We show the complementary information provided by the phase and magnitude of the reconstructed wavefield greatly improves the quality of the resulting estimate of the transmission function of an object without the need for a priori information. Coherent xray diffractive imaging is a powerful method for studies on nonperiodic structures on the nanoscale. Citeseerx document details isaac councill, lee giles, pradeep teregowda. Scanning coherent diffractive imaging methods for actinic. The availability of thirdgeneration synchrotrons and ultimately xray freeelectron lasers1 is driving the development of many new methods of microscopy. Coherent diffraction imaging lensless imaging eric welch, sara mohamed, ling zeng, weilun qin august 7, 2015. Image reconstruction from a single diffraction pattern has hitherto been possible only for small, isolated samples, presenting a fundamental limitation on the cdi method. Facing the phase problem in coherent diffractive imaging via. It has attracted a great deal of attention and interest owing to its unique. The main topics that will be tackled are phasesensitive xray imaging, synchrotron xray tomography, coherent xray imaging methods with xray optics andor lensless and ultrafast time resolved imaging using fels. May 1718, 2010 brookhaven national laboratory, bldg. The possibility to perform keyhole coherent diffraction experiments has been demonstrated also for electrons in edi, obtaining the kedi.
Index termsankylography, coherent diffraction imaging. Efficient coherent diffractive imaging for sparsely. At nlcta, we exploit such techniques for the diagnosis of the density distribution of the intense electron beams typically utilized in an xray fel itself. Coherence and sampling requirements for diffractive imaging. The camera consists of a laterally graded multilayer mirror, which reflects the diffraction pattern onto a ccd detector. Tabletop nanometer extreme ultraviolet imaging in an extended. Multiple defocused coherent diffraction imaging osa publishing. Efficient coherent diffractive imaging for sparsely varying objects yoav shechtman,1, yonina c. Journal of applied crystallography 43, 15351539 2010. The modulus image was scaled to values in the range 0. Xfel singleparticle diffractive imaging pipeline involves recording singleshot diffraction patterns of the targetobject before the destruction due to ionization and coloumb explosion top, computational purification for expected singleparticle diffraction patterns, orientation determination, classification into 2d class averages, and the 3d merging of intensities in the. Reconstruction of an object from the modulus of its fourier transform. Highresolution scanning coherent xray diffraction microscopy.
Up to now, this has been limited to intense coherent pulses from a free electron laser. Fresnel coherent diffractive imaging or fcdi has been shown to be fast converging 23 as well as robust in the presence of partial coherence 24, 25, and has been used to image a malariainfected red blood cell 26. Coherent diffractive imaging cdi allows for high resolution imaging without lenses. In situ observation of dynamic electrodeposition processes. Soft xray keyholecoherent diffractive imaging kcdi dynamic electrodeposition was monitored in situ through kcdi at. Xray coherent diffraction imaging cdi methods have recently demonstrated impressive potential for characterizing such materials with a high spatial resolution and elemental sensitivity. Coherent diffractive imaging cdi is a lensless technique for 2d or 3d reconstruction of the image of nanoscale structures such as nanotubes, nanocrystals, porous nanocrystalline layers, defects, potentially proteins, and more.
Diffractive imaging using coherent xray light sources nanowerk news in 1999, ucla professor john miao pioneered a technique called coherent diffractive imaging, or cdi, which allows scientists to recreate the 3d structure of noncrystalline samples or nanocrystals. Coherence measurements and coherent diffractive imaging at. Generalized tabletop euv coherent diffractive imaging in a. In situ coherent diffractive imaging yuan hung lo1,2, lingrong zhao1,3, marcus gallagherjones1, arjun rana1, jared j. Coherent diffractive imaging cdi is a lensless technique for 2d or 3d reconstruction of the. An intense 25 fs, 4 10 wcm2 pulse, containing 1012 photons at 32 nm wavelength, produced a coherent diffraction pattern from a nanostructured nonperiodic object, before destroying it at 60,000 k. The newly emerging technology of xray freeelectron lasers xfels has the potential to revolutionise molecular imaging. Use of a complex constraint in coherent diffractive imaging. Coherent diffractive imaging of microtubules using an x. We demonstrate the first generalized tabletop euv coherent microscope that can image extended, nonisolated, nonperiodic, objects. The achievement was extremely significant because although xray. Coherent x rays provided by the xray freeelectron laser fel have kindled strong interest in sophisticated diffraction imaging techniques. A novel xray camera assured single photon detection. Coherent diffractive imaging using hhg nanoscale imaging is critical for progress in many areas, as we learn to master science and technology at the smallest dimensions.
Polycdi extends the capabilities of coherent diffractive imaging cdi, a lensless imaging technique that has been a mainstay for experiments observing matter on. Lensless imaging is a relatively new coherent imaging technique that is complementary to zoneplate imaging 9. Xray coherent diffractive imaging cdi is currently under intensive development for a wide range of applications in the materials 1,2,3 and biological sciences 4,5, due in part to its ability to. Keyhole coherent diffractive imaging nature physics. Xray coherent diffractive imaging cdi is currently under intensive development for a wide range of applications in the materials 1,2,3 and biological sciences 4,5, due in part to its ability to provide spatial resolution beyond the limits imposed by image forming optics 6. Among these techniques, coherent diffractive imaging cdi is one of the most promising, offering nanometrescale imaging of noncrystallographic samples. Wholecell phase contrast imaging at the nanoscale using. Among the techniques which are currently being developed, coherent diffractive imaging cdi is emerging as one of the most promising, offering the potential of very high resolution lensless imaging of noncrystallographic samples. Sayre proposed, following that observation, the idea of diffraction imaging of noncrystalline samples sayre, 1980. Lcls, the worlds first hard xray laser, is leading a revolution in coherent xray imaging. In keyhole coherent diffractive imaging kcdi, a beam is focused and the object is. Ultramicroscopy 101 2004149152 coherence and sampling requirements for diffractive imaging j. Letters keyhole coherent diffractive imaging brian abbey1, keith a.
We describe a camera to record coherent scattering patterns with a softxray freeelectron laser fel. Here we report on a form of imaging we term keyhole cdi, which can. Scanning coherent diffractive imaging methods for actinic extreme ultraviolet mask metrology patrick helfenstein, istvan mohacsi, rajendran rajeev, and yasin ekinci paul scherrer institute, reaktorstrasse 1, 5232 villigen psi, switzerland abstract. Bragg coherent diffractive imaging bcdi emerged recently as a powerful tool to probe the internal deformation. Cdi which requires overlapping diffraction patterns, keyhole cdi needs only. Soft xray keyholecoherent diffractive imaging kcdi dynamic electrodeposition was monitored in situ through kcdi at the sxri beamline of the australian synchrotron 31. Xray free electron laser priority strategy program of mext, and the sentan of jst. Considerations for threedimensional image reconstruction from experimental data in coherent diffractive imaging. Hawk is a package for the analysis and phasing of diffraction patterns from single particle diffraction experiments. Here, we present a new approach to singleshot cdi that is based on immersing specimens in nanodroplets, henceforth referred to as droplet coherent diffractive imaging dcdi. An alternative approach to nanoscale dichroic microscopy is resonant xray coherent diffractive imaging cdi, whereby the diffraction pattern formed by scattering a coherent xray beam from a sample is inverted numerically to form an image of the sample. Camera for coherent diffractive imaging and holography. Although directly illuminated ccds are currently being successfully used, the limitations they impose on dynamic range and readout speed will need to be addressed as the techniques mature.
The data were collected using ccdimageserver software developed at the aps. Correction of chromatic aberration by using a diffractive lens a hybrid imaging system consisting of both refractive and diffractive lenses is analyzed, especially, with the undesired diffraction orders of the diffractive lens taken into account. Xray science and the australian synchrotron research program. Coherent diffraction imaging cdi or coherent diffractive. First ultrafast diffraction image of a mimivirus, paving the way for new methods to image life. Lensless diffractive imaging using tabletop coherent high. In 1999, ucla professor john miao pioneered a technique called coherent diffractive imaging, or cdi, which allows scientists to recreate the 3d structure of. Femtosecond diffractive imaging with a softxray freeelectron laser. In situ coherent diffractive imaging nature communications. Diffractive imaging using coherent xray light sources jianwei miao1, tetsuya ishikawa2, ian k. In cdi, the spatial resolution is not limited by the quality of the optical elements but.
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